Antidepressants are widely prescribed, but their efficacy relative to placebo is modest, in part because the clinical diagnosis
of major depression encompasses biologically heterogeneous conditions. Here, we sought to identify a neurobiological signature of response to antidepressant treatment as compared to placebo.

https://sci-hub.tw/downloads-ii/2020-02-10/e3/10.1038@s41587-019-0397-3.pdf